Toll样受体4与脓毒症相关性的研究进展 |
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引用本文: | 刘雪燕,徐勇. Toll样受体4与脓毒症相关性的研究进展[J]. 中国生物制品学杂志, 2012, 25(12): 1723-1728 |
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作者姓名: | 刘雪燕 徐勇 |
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作者单位: | 1. 暨南大学医学院附属二院深圳市人民医院急诊ICU 广东深圳 518020 2. 深圳市坪山人民医院 广东深圳 518020 |
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基金项目: | 广东省卫生厅资助项目(项目编号:A2011535) |
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摘 要: | 重症脓毒症(Sever sepsis)及脓毒性休克(Sepsis shock)是当前危重病患者的主要死亡原因。内毒素受体4(Toll-like receptor,TLR4)是革兰阴性菌细胞壁脂多糖的受体,TLR4及其信号通路基因多态性在脓毒症的发生发展过程中起着重要的作用。目前大部分针对单一炎症细胞因子的脓毒症治疗均宣告失败。由于TLR4的重要地位,靶向性针对TLR4及其信号通路的治疗充满希望。现就TLR4和信号通路基因多态性与脓毒症易感性及其调节剂之间的关系作一综述。
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关 键 词: | Toll样受体4 信号通路 脓毒症 基因多态性 |
Advances in research on relationship between Toll-like receptor 4 and sepsis |
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Abstract: | Severe sepsis and sepsis shock are the major causes of deaths at present.Toll-like receptor 4(TLR4)is the receptor of lipopolysaccharide in cell walls of gram-negative bacteria.The genetic polymorphisms of TLR4 and its signal pathway play important roles in ongoing of sepsis.Most of the treatments against single inflammatory cytokine are declared fail.Because of the important role of TLR4,the targeting treatments against TLR4 and signal pathway are hopeful.This paper reviews the relationship of genetic polymorphisms of TLR4 and its signal pathway to the susceptibility and regulator of sepsis. |
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Keywords: | Toll-like receptor 4(TLR4) Signal pathway Sepsis Genetic polymorphism |
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