| 阿昔洛韦合成工艺的改进 |
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| 引用本文： | 陈红兵,曹克林,李玉萍.阿昔洛韦合成工艺的改进[J].山西化工,2000(2). |
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| 作者姓名： | 陈红兵 曹克林 李玉萍 |
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| 作者单位： | 山西农业大学基础部，山西太明化工有限公司，太谷县人民医院 山西 太谷 030801 |
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| 摘 要： | 以氰乙酸乙酯为起始原料,制得鸟嘌吟,再经酰化、缩合、氨解反应即可制得高效抗病毒药阿昔洛韦。实验表明,该工艺使用原料简单易得,反应条件温和,成本降低,总收率52％,更加适合于工业化生产。
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| 关 键 词： | 阿昔洛韦 鸟嘌呤 合成 |
Improved Synthesis of Acyclovir |
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| Chen Hongbin Cao Kelin Li Yuping.Improved Synthesis of Acyclovir[J].Shanxi Chemical Industry,2000(2). |
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| Authors: | Chen Hongbin Cao Kelin Li Yuping |
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| Affiliation: | Chen Hongbin1 Cao Kelin2 Li Yuping3 |
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| Abstract: | High efficient anti-virus medicine acyclovir is brought out using ethyl cyanideacetatc as a raw material by several processes ,of guanine then acetylation condensation and hydrolysis with ammonia. It turns out through experiments that the raw material is easy to get, the processes are easy to control and the cost can be lowered with a final output rate of 52 %. It is more fit for industrialized manufacturing. |
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| Keywords: | acyclovir guanine synthesis |
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