| 四乙酰野黄芩素的合成 |
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| 引用本文： | 周荣光,杨兆祥,张颖君,赵加强.四乙酰野黄芩素的合成[J].云南化工,2010,37(3):32-38. |
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| 作者姓名： | 周荣光 杨兆祥 张颖君 赵加强 |
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| 作者单位： | 1. 昆明制药集团药物研究院,云南,昆明,650100
2. 中国科学院昆明植物研究所植物化学与西部植物资源持续利用国家重点实验室,云南,昆明,650204 |
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| 摘 要： | 以灯盏花素为原料,在乙二醇-水-盐酸体系中,将原料中的灯盏花乙素水解转化为野黄芩素;中间体野黄芩素在醋酸钾与吡啶的共同催化作用下,经醋酐酰化制得最终产物四乙酰野黄芩素。第一步反应产率为81.3%,所得产物野黄芩素纯度达99.8%;第二步反应产率86.1%,所得产物四乙酰野黄芩素纯度达98.4%。所得产物结构经UV,IR,MS,13CNMR,1HNMR所证实。
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| 关 键 词： | 灯盏花素 灯盏花乙素 野黄芩素 四乙酰野黄芩素 |
Synthesis of Tetraacetyl Scutellarein |
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| ZHOU Rong-guang,YANG Zhao-xiang,ZHANG Ying-jun,ZHAO Jia-qiang.Synthesis of Tetraacetyl Scutellarein[J].Yunnan Chemical Technology,2010,37(3):32-38. |
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| Authors: | ZHOU Rong-guang YANG Zhao-xiang ZHANG Ying-jun ZHAO Jia-qiang |
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| Affiliation: | 1.Institute for Drug Research and Development of Kunming Pharmaceutical Corporation,Kunming 50100,China;2.State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650204,China) |
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| Abstract: | Objective： To synthesize tetraacetyl scutellarein.Method： First,scutellarein was synthesized via a hydrolysis reaction of scutellarin,the main active component of breviscapine,in HCl/EG/H2O solution;then,tetraacetyl scutellarein was synthesized by acetylation of scutellarein with acetic anhydride,catalyzed by CH3COOK/Py.Results： The first reaction has a yield of 81.3%,the purity of the compound scutellarein is 99.8%;the second reaction has a yield of 86.1%,the purity of the compound tetraacetyl scutellarein is 98.4%.The structures of these synthesized compounds were identified by UV,IR,MS,13CNMR and 1HNMR.Conclusion： Tetraacetyl scutellarein was synthesized successfully starting from breviscapine.The method is simple,has the advantages of easy obtaining raw material and mild reaction condition,suitable for its industrialized production. |
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| Keywords: | breviscapine scutellarin scutellarein tetraacetyl scutellarein |
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