Crossing the midline: a study of four-year-old children |
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Authors: | DP Screws BL Eason PR Surburg |
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Affiliation: | Institut für Physiologische Chemie I, Heinrich-Heine-Universit?t Düsseldorf, Germany. |
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Abstract: | Selenomethionine, an amino acid occurring in proteins in place of methionine, reacts efficiently with oxidants, e.g., peroxynitrite, a biological oxidant generated in inflammatory states, to produce the oxidation product, methionine selenoxide. The present work describes the rapid and efficient reduction of the selenoxide to selenomethionine by glutathione in a stoichiometric reaction utilizing two equivalents of thiol. This nonenzymatic reaction establishes a defense line against peroxynitrite or other oxidants by selenomethionine residues in proteins, maintained by the ubiquitous thiol, glutathione. |
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