| 18F-FDG的制备及在小鼠体内分布研究 |
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| 引用本文： | 唐刚华,王明芳,吴湖炳,高晓,李志,罗磊,黄祖汉. 18F-FDG的制备及在小鼠体内分布研究[J]. 核技术, 2001, 24(5) |
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| 作者姓名： | 唐刚华 王明芳 吴湖炳 高晓 李志 罗磊 黄祖汉 |
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| 作者单位： | 第一军医大学南方医院 |
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| 摘 要： | 采用PETtrace回旋加速器 -FDG合成系统 ,通过18O(p ,n) 18F核反应和亲核取代反应制备18F -FDG ,放化产率约为 54% ,放化纯度大于 95%。小鼠体内分布实验表明 ,18F -FDG在心肌和脑中有较高的摄取率 ,且放射性持续时间较长 ,并通过肾脏迅速排出。注入18F -FDG 30min后 ,放射性在血和各脏器中的分布逐渐达到平衡。制备的18F -FDG适于临床PET研究和诊断
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| 关 键 词： | 18F-FDG 合成 体内分布 |
Synthesis and tissue distribution in mice of 18F-FDG |
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| TANG Ganghua,WANG Mingfang,WU Hubing,GAO Xiao,LI Zhi,LUO Lei,HUANG Zuhan. Synthesis and tissue distribution in mice of 18F-FDG[J]. Nuclear Techniques, 2001, 24(5) |
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| Authors: | TANG Ganghua WANG Mingfang WU Hubing GAO Xiao LI Zhi LUO Lei HUANG Zuhan |
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| Abstract: | Deoxy-2- 18 F-fluoro-D-glucose ( 18 F-FDG) was synthesized via nuclear reaction 18 O(p,n) 18 F and nucleophilic substitution reaction by PET trace Cyclotron-FDG Synthesis System. The corrected radiochemical yield was about 54% and the radiochemical purity was above 95% by HPLC and TLC. The distribution of 18 F-FDG in mice showed that the higher uptake rates of 18 F-FDG in heart and brain were found, the radioactivity reteined in heart and brain for longer time and the radioactivity in kidney was rapidly cleared. The radioactivity in blood and organs dropped very slowly 30min after injection of 18 F-FDG. The synthetic 18 F-FDG allowed for PET study and diagnosis of patients. |
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| Keywords: | F-FDG Synthesis Distribution in vivo |
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