Secondary Metabolites of the Endophytic Fungus Lachnum abnorme from Ardisia cornudentata |
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| Authors: | Hsun-Shuo Chang Chu-Hung Lin Yi-Shuan Chen Hui-Chun Wang Hing-Yuen Chan Sung-Yuan Hsieh Ho-Cheng Wu Ming-Jen Cheng Gwo-Fang Yuan Shan-Yu Lin Yue-Jin Lin Ih-Sheng Chen |
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| Affiliation: | 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; (H.-S.C.); (Y.-S.C.); (Hu.-C.W.); (Ho.-C.W.);2School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan; (C.-H.L.); (S.-Y.L.); (Y.-J.L.);3Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu 300, Taiwan; (H.-Y.C.); (S.-Y.H.); (G.-F.Y.) |
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| Abstract: | Fractionation of an EtOAc-soluble fraction of the solid fermentate of an endophytic fungus, Lachnum abnorme Mont. BCRC 09F0006, derived from the endemic plant, Ardisia cornudentata Mez. (Myrsinaceae), resulted in the isolation of three new chromones, lachnochromonins D–F (1–3), one novel compound, lachabnormic acid (4), along with nine known compounds (5–13). Their structures were elucidated by spectroscopic analyses. Alternariol-3,9-dimethyl ether (6) was given the correct data as well as 2D spectral analyses for the first time. This is the first report of the isolation of one unprecedented compound 4 from Lachnum genus, while all known compounds were also found for the first time from Lachnum. The effects of some isolates (3, 4, 7–9, 10, and 13) on the inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 murine macrophages were also evaluated. Several compounds exhibited weak inhibitory activity on lipopolysaccharide (LPS)-stimulated NO production in RAW 264.7 macrophages. |
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| Keywords: | Lachnum abnorme Ardisia cornudentata myrsinaceae stem anti-inflammatory activity |
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