Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators |
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| Authors: | Lucía Pérez-Regidor Malik Zarioh Laura Ortega Sonsoles Martín-Santamaría |
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| Affiliation: | Department of Chemical & Physical Biology, Centro de Investigaciones Biológicas, CIB-CSIC, C/Ramiro de Maeztu, 9, 28040 Madrid, Spain; (L.P.-R.); (M.Z.); (L.O.) |
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| Abstract: | This review aims to summarize the latest efforts performed in the search for novel chemical entities such as Toll-like receptor (TLR) modulators by means of virtual screening techniques. This is an emergent research field with only very recent (and successful) contributions. Identification of drug-like molecules with potential therapeutic applications for the treatment of a variety of TLR-regulated diseases has attracted considerable interest due to the clinical potential. Additionally, the virtual screening databases and computational tools employed have been overviewed in a descriptive way, widening the scope for researchers interested in the field. |
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| Keywords: | Toll-like receptor TLR modulators virtual screening drug discovery computational approaches |
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