| 基于吸收光谱技术的皮肤胆固醇无创检测系统设计 |
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| 引用本文： | 许超, 方朝晖, 董美丽, 等. 基于吸收光谱技术的皮肤胆固醇无创检测系统设计[J]. 光电工程, 2018, 45(4): 170587. doi: 10.12086/oee.2018.170587 |
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| 作者姓名： | 许超 方朝晖 董美丽 张元志 倪敬书 王贻坤 朱灵 王玲 刘勇 |
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| 作者单位： | 1. 中国科学院合肥物质科学研究院应用技术所，安徽生物医学光学仪器工程技术研究中心，安徽省医用光学诊疗技术与装备工程实验室，安徽 合肥 230031; 2. 中国科学技术大学，安徽 合肥 230026; 3. 安徽中医药大学第一附属医院，安徽 合肥 230000; 4. 皖江新兴产业技术发展中心，安徽 铜陵 244000 |
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| 基金项目： | 国家科技支撑计划(2015BAI01B04)；国家中医临床研究基地业务建设第二批科研专项(2015D05)；国家中医药管理局国家基本公共卫生服务项目(20151012)；安徽省科技重大专项(15CZZ02019)；安徽省自然科学基金项目(1508085QF141)；中国科学院STS项目(KFJ-SW-STS-161) |
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| 摘 要： | 利用STM32微处理器，设计了一种基于吸收光谱技术的皮肤胆固醇无创检测系统，通过微型光谱仪获得有色产物的吸收光谱信息，间接得到人体皮肤胆固醇相对含量。本系统设计了一款高精度可调LED恒流源，LED光强的波动范围控制在±1%以内。还设计了一种结构简单、试剂用量少、不需要确切的检测试剂体积的液体限位装置，实现被测液体浓度的准确测量。通过检测梯度浓度CuSO4溶液，验证了系统应用于不同浓度溶液定量检测的准确性。采用本系统对动脉粥样硬化性疾病患者和对照人群的皮肤胆固醇进行检测，检测结果在统计学上有显著性差异，初步验证系统可用于人体皮肤胆固醇的检测。
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| 关 键 词： | 皮肤胆固醇 吸收光谱 嵌入式系统 微型光谱仪 恒流源 限位结构 |
| 收稿时间： | 2017-10-31 |
| 修稿时间： | 2018-01-26 |
Design of non-invasive skin cholesterol detection system based on absorption spectroscopy |
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| Xu Chao, Fang Zhaohui, Dong Meili, et al. Design of non-invasive skin cholesterol detection system based on absorption spectroscopy[J]. Opto-Electronic Engineering, 2018, 45(4): 170587. doi: 10.12086/oee.2018.170587 |
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| Authors: | Xu Chao Fang Zhaohui Dong Meili Zhang Yuanzhi Ni Jingshu Wang Yikun Zhu Lin Wang Lin Liu Yong |
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| Affiliation: | 1. Anhui Provincial Engineering Laboratory for Medical Optical Diagnosis & Treatment Technology and Instrument, Anhui Provincial Engineering Technology Research Center for Biomedical Optical Instrument, Institute of Applied Technology, Hefei Institute of Physical Science, Chinese Academy of Science, Hefei, Anhui 230031, China; 2. University of Science and Technology of China, Hefei, Anhui 230026, China; 3. First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui 230000, China; 4. Wanjiang Center for Development of Emerging Industrial Technology, Tongling, Anhui 244000, China |
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| Abstract: | Using STM32 microprocessor, a non-invasive skin cholesterol detection system based on absorption spectroscopy was designed. The relative cholesterol content of human skin was indirectly obtained by absorption spectrum information of colored products which was detected by micro-spectrometer. The system was designed with a high-precision adjustable LED constant current source, and the fluctuation range of LED light intensity is controlled within ±1%. A liquid limit device with a simple structure, a small amount of reagents, and no need for an exact detection reagent volume was also designed to achieve accurate measurement of the measured liquid concentration. By detecting the concentration of CuSO4 solution, the accuracy of the system for quantitative detection of different concentrations of solution was verified. Using this system to detect the skin cholesterol of patients with atherosclerotic disease and control population, the test results have statistically significant differences, which preliminarily verifies that system can be used for human skin cholesterol detection. |
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| Keywords: | skin cholesterol absorption spectrum embedded systems micro spectrometer constant current source limit structure |
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