Promoter analysis of the human mismatch repair gene hMSH2 |
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Authors: | Y Iwahashi E Ito Y Yanagisawa Y Akiyama Y Yuasa T Onodera K Maruyama |
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Affiliation: | Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain. |
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Abstract: | On the basis of both the interleukin-2-receptor (IL-2R) alpha-chain expression on 16-day-old fetal rat thymocytes and the occurrence of interleukin-2 (IL-2) mRNA-containing cells early during rat thymus ontogeny, we have investigated the possible role of IL-2/IL-2R complex in rat T-cell maturation. For this purpose, we analyzed the effects of the addition of either recombinant rat IL-2 or anti-CD25 (OX-39)-blocking monoclonal antibodies to fetal thymus organ cultures (FTOC), established from 16-day-old rat embryos. IL-2 stimulated the growth of thymocytes and, as a result, induced T-cell differentiation, whereas OX-39 mAb blocked the maturation of thymic-cell progenitors. Accordingly, these results support the involvement of IL-2/IL-2R complex in rat T-cell development. |
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