Carbon nanotubes in microfluidic lab-on-a-chip technology: current trends and future perspectives |
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| Authors: | Amir Ghasemi Hamed Amiri Hossein Zare Maryam Masroor Akbar Hasanzadeh Ali Beyzavi Amir R. Aref Mahdi Karimi |
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| Affiliation: | 1.Department of Materials Science and Engineering,Sharif University of Technology,Tehran,Iran;2.Advances Nanobiotechnology and Nanomedicine Research Group (ANNRG),Iran University of Medical Sciences,Tehran,Iran;3.Biomaterials Group, Materials Science and Engineering Department,Iran University of Science and Technology,Tehran,Iran;4.School of Metallurgy and Materials Engineering, College of Engineering,University of Tehran,Tehran,Iran;5.School of Mechanical Engineering,Boston University,Boston,USA;6.Department of Medical Oncology, Belfer Center for Applied Cancer Science, Dana-Farber Cancer Institute,Harvard Medical School,Boston,USA;7.Cellular and Molecular Research Center,Iran University of Medical Sciences,Tehran,Iran;8.Department of Medical Nanotechnology, Faculty of Advanced Technologies in Medicine,Iran University of Medical Sciences,Tehran,Iran;9.Applied Biotechnology Research Center, Teheran Medical Sciences Branch,Isclamic Azad University,Teheran,Iran;10.Wellman Center for Photomedicine, Massachusetts General Hospital,Harvard Medical School,Boston,USA;11.Department of Dermatology,Harvard Medical School,Boston,USA;12.Harvard-MIT Division of Health Sciences and Technology,Cambridge,USA;13.Research Center for Science and Technology in Medicine,Tehran University of Medical Sciences,Tehran,Iran |
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| Abstract: | Advanced nanomaterials such as carbon nanotubes (CNTs) display unprecedented properties such as strength, electrical conductance, thermal stability, and intriguing optical properties. These properties of CNT allow construction of small microfluidic devices leading to miniaturization of analyses previously conducted on a laboratory bench. With dimensions of only millimeters to a few square centimeters, these devices are called lab-on-a-chip (LOC). A LOC device requires a multidisciplinary contribution from different fields and offers automation, portability, and high-throughput screening along with a significant reduction in reagent consumption. Today, CNT can play a vital role in many parts of a LOC such as membrane channels, sensors and channel walls. This review paper provides an overview of recent trends in the use of CNT in LOC devices and covers challenges and recent advances in the field. CNTs are also reviewed in terms of synthesis, integration techniques, functionalization and superhydrophobicity. In addition, the toxicity of these nanomaterials is reviewed as a major challenge and recent approaches addressing this issue are discussed. |
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