鱼类体表粘液抗菌肽的研究进展

鱼类体表粘液中的抗菌肽是对细菌起直接抑制作用的一类重要物质,是鱼体天然免疫的重要组成部分,它具有抗细菌、真菌、病毒和肿瘤作用,且不易产生抗药性,具有广阔的应用前景。本文综述了鱼类体表粘液抗菌肽的抑菌活性、分离纯化、基因工程、作用机理及其在食品方面的应用前景。 

Progress research on fish epidermal mucus antimicrobial peptides

The research on fish epidermal mucus ingredients had made certain progress in recent years, such as complement and interferon against bacteria indirectly, as well as lectins, lysozyme and non-specific immune factors against bacteria directly. However, the research on fish epidermal mucus antimicrobial peptides was less. Fish epidermal mucus antimicrobial peptides were important parts of innate immunity to bacterial invasion.Except for broad-spectrum antibacterial activity, epidermal mucus antimicrobial peptides have more biological activities on the resistance of fungi, virus, parasite and tumor, but scarcely induce drug resistance, which shows an obvious application prospect. It was summarized progress of antimicrobial peptides on antibacterial activity, purification, gene engineering, mechanism of action and application prospect on the food industry.