| 甘薯叶柄藤类黄酮的抗肿瘤作用研究 |
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| 引用本文： | 罗丽萍,高荫榆,洪雪娥,夏冬华,陈才水. 甘薯叶柄藤类黄酮的抗肿瘤作用研究[J]. 食品科学, 2006, 27(8): 248-250 |
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| 作者姓名： | 罗丽萍 高荫榆 洪雪娥 夏冬华 陈才水 |
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| 作者单位： | 南昌大学食品科学教育部重点实验室 |
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| 摘 要： | 研究薯蔓黄酮(FSPV)对瘤株和动物的抗肿瘤作用。采用MTT法研究FSPV对4种瘤株生长的抑制作用;以动物移植性肿瘤肉瘤S180为模型,以环磷酰胺为阳性对照,以生理盐水为阴性对照,观察FSPV对动物的抗肿瘤作用。结果表明:FSPV能显著抑制4种瘤株的生长,并呈一定的剂量浓度关系;尤其对HL-60瘤株效果最佳。FSPV对S180荷瘤小鼠有较强的抑瘤作用(p<0.05),并以中剂量(400mg/kgbw)的抑瘤率最高;结论:FSPV对4种瘤株和移植性S180肉瘤小鼠具有抗肿瘤作用。
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| 关 键 词： | 甘薯叶柄藤 黄酮 抗肿瘤作用 MTT法 |
| 文章编号： | 1002-6630（2006）08-0248-03 |
| 收稿时间： | 2006-03-31 |
| 修稿时间： | 2006-03-31 |
Study on Anti-tumor Effects of Flavonoids Extracted from Sweet Potato Leaf, Stalk and Stem |
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| LUO Li-ping,GAO Yin-yu,HONG Xue-e,XIA Dong-hua,CHEN Cai-shui. Study on Anti-tumor Effects of Flavonoids Extracted from Sweet Potato Leaf, Stalk and Stem[J]. Food Science, 2006, 27(8): 248-250 |
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| Authors: | LUO Li-ping GAO Yin-yu HONG Xue-e XIA Dong-hua CHEN Cai-shui |
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| Affiliation: | Key Laboratory of Food Science,Ministry of Education,Nanchang University,Nanchang 330047,China |
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| Abstract: | The antitumor effects of FSPV were studied in this paper.By using MTT assay and dye exclusion method,the inhibitory effects on 4 tumor cell lines in vitro of FSPV were studied.Cyclophosphamide was the positive control and saline the negative control.S180-bearing mice were used as animal model.The changes of tumor weight in vitro were investigated when FSPV were used.Results:The growth of 4 tumor cells is inhibited by FSPV significantly in dose-dependent manner.Especially the inhibitory effect on the HL-60 is specific up to 70.95%.The antitumor effect of FSPV on the S180 bearing mice is significant.The inhibitory rate is highest when the dose is 400mg/kg bw.Conclusion:FSPV have the antitumor effects on the 4 tumor cell lines and S180-bearing mice. |
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| Keywords: | sweet potato leaf, stalk and stem flavonoids anti-tumor effect MTT assay |
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