Genetically engineered metal ion binding sites on the outside of a Channel's transmembrane beta-barrel |
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| Authors: | JJ Kasianowicz DL Burden LC Han S Cheley H Bayley |
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| Affiliation: | National Institute of Standards and Technology, Biotechnology Division, Gaithersburg, Maryland 20899, USA. john.kasianowicz@nist.gov |
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| Abstract: | We are exploring the ability of genetically engineered versions of the Staphylococcus aureus alpha-hemolysin (alphaHL) ion channel to serve as rationally designed sensor components for analytes including divalent cations. We show here that neither the hemolytic activity nor the single channel current of wild-type alphaHL was affected by Zn(II)]
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