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Genetically engineered metal ion binding sites on the outside of a Channel's transmembrane beta-barrel
Authors:JJ Kasianowicz  DL Burden  LC Han  S Cheley  H Bayley
Affiliation:National Institute of Standards and Technology, Biotechnology Division, Gaithersburg, Maryland 20899, USA. john.kasianowicz@nist.gov
Abstract:We are exploring the ability of genetically engineered versions of the Staphylococcus aureus alpha-hemolysin (alphaHL) ion channel to serve as rationally designed sensor components for analytes including divalent cations. We show here that neither the hemolytic activity nor the single channel current of wild-type alphaHL was affected by Zn(II)]
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