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Organocatalysis in Enantioselective α‐Functionalization of 2‐Cyanoacetates |
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| Authors: | María D Díaz‐de‐Villegas Jos A Glvez Ramn Badorrey Pilar Lpez‐Ram‐de‐Víu |
| Abstract: | Recent progress in asymmetric organocatalysis has led to the development of several asymmetric transformations that employ various substrates. Among these, cyanoacetates have emerged as excellent nucleophiles in conjugate addition, alkylation, Mannich and α‐heterofunctionalization reactions. In this review we discuss the enantioselective functionalization of 2‐cyanoacetates through organocatalytic reactions.  |
| Keywords: | cyanides cyano esters enantioselectivity organic catalysis synthetic methods |