|
|||||
|
|
Metal‐Free Regioselective β‐Alkylation of Pyrroles with Carbonyl Compounds and Hydrosilanes: Use of a Brønsted Acid as a Catalyst |
|
| Authors: | Shota Nomiyama Teruhisa Tsuchimoto |
| Abstract: | A Brønsted acid, trifluoromethanesulfonimide HN(SO2CF3)2], was found to catalyze reductive β‐alkylation of pyrroles with carbonyl compounds and hydrosilanes. This metal‐free process features lower catalyst loadings compared to the original indium variant and exclusive generation of β‐alkylpyrroles.  |
| Keywords: | alkylation Brø nsted acids heterocycles hydrides regioselectivity |