| 介电材料辅助的微波冷冻干燥的实验研究 |
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| 引用本文： | 王维,潘艳秋,赵明举,陈国华.介电材料辅助的微波冷冻干燥的实验研究[J].高校化学工程学报,2010,24(6). |
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| 作者姓名： | 王维 潘艳秋 赵明举 陈国华 |
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| 作者单位： | 大连民族学院生命科学学院;香港科技大学化学与生物分子工程系;大连理工大学化工学院; |
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| 基金项目： | 香港研资局(RGC)基金，大连民族学院博士后启动基金，辽宁省自然科学基金 |
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| 摘 要： | 设计、加工和装配了一套实验室规模的微波冷冻干燥装置,旨在实验验证介电材料对微波冷冻干燥液体物料的强化作用。介电材料用烧结的碳化硅(SiC),石英玻璃作为介电材料的参照物;甘露醇,一种典型的药物赋形剂被选为待干溶液中的溶质。实验结果表明使用介电材料可以有效地强化微波冷冻干燥过程。与传统冷冻干燥相比干燥速率大大加快,在试验条件下干燥时间可以节省20%。微波加热逐渐生效并且主要体现在干燥过程的后半部分。当溶液中的固含量很低或者固体物质具有很小的介电损耗因子时,如果不用介电材料,微波加热的效果不明显。
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| 关 键 词： | 微波冷冻干燥 介电材料 药物赋形剂 水溶液 干燥曲线 |
Experimental Investigation on Freeze Drying with Dielectric Material Assisted Microwave Heating |
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| WANG Wei,PAN Yan-qiu,ZHAO Ming-ju,CHEN Guo-hua.Experimental Investigation on Freeze Drying with Dielectric Material Assisted Microwave Heating[J].Journal of Chemical Engineering of Chinese Universities,2010,24(6). |
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| Authors: | WANG Wei PAN Yan-qiu ZHAO Ming-ju CHEN Guo-hua |
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| Affiliation: | WANG Wei1,3,PAN Yan-qiu2,ZHAO Ming-ju1,CHEN Guo-hua3(1.College of Life Science,Dalian Nationalities University,Dalian 116600,China,2.School of Chemical Engineering,Dalian University of Technology,Dalian 116012,3.Department of Chemical and Biomolecular Engineering,The Hong Kong University of Science and Technology,Hong Kong,China) |
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| Abstract: | Aiming at experimentally verifying the beneficial effect of the dielectric material on freeze drying with microwave heating,a laboratory scaled microwave freeze drying apparatus was designed,fabricated and assembled.Sintered silicon carbide(SiC) was used as the dielectric material as well as quartz as a reference substance.Mannitol,a typical pharmaceutical excipient,was selected as the solute in the being freeze dried aqueous solution.The results show that use of dielectric material in microwave freeze dryi... |
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| Keywords: | microwave freeze drying dielectric material excipient aqueous solution drying curve |
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