Effect of immobilization of poly(γ-glutamic acid) on the biocompatibility of electrospun poly (L-lactide) mats |
| |
Authors: | Chien-Hsin Chen Ming-Chien Yang Da-Guang Yu Chi-Hsiung Jou |
| |
Affiliation: | 1.Department of Materials Science and Engineering,National Taiwan University of Science and Technology,Taipei,Taiwan;2.Department of Materials and Textiles,Oriental Institute of Technology,New Taipei City,Taiwan |
| |
Abstract: | In this study, poly(L-lactide) (PLLA) non-woven mats were prepared by electrospinning technique, followed by treating with oxygen plasma and grafting with 3-aminopropyl triethoxysilane (APTES), then immersed in poly(γ-glutamic acid) (γ-PGA) solution to form a layer of γ-PGA on the surface. In so doing, hydrophobic PLLA would become highly hydrophilic. Through characterization of hydrophilicity and biocompatibility, the feasibility of these modified mats for wound dressing was evaluated. The results show that after the grafting of γ-PGA, the swelling ratio increased greatly from 7% for pristine PLLA mat to 321% for γ-PGA-grafted PLLA mat, and the contact angle decreased from 112° to 25°. In vitro cytocompatibility tests against L929 fibroblast show that γ-PGA-grafted PLLA was non-cytotoxic. In addition, the proliferation of fibroblasts was higher on γ-PGA-grafted PLLA than on pristine PLLA. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|