Deposition of dietary epoxides in tissues of rats |
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Authors: | Fioriti J A Buide N Sims R J |
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Affiliation: | (1) Technical Center, General Foods Corporation, 10602 White Plains, New York |
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Abstract: | Epididymal fat pad lipids from rats fed trivernolin at the 4.8% level in the diet for 90 days were found to contain 6.1% epoxyoleic
acid. No epoxides were detected in the serum lipids and only trace amounts were found in the liver lipids. TLC, GLC and a
specific color reaction with picric acid were used to identify this fatty epoxide in the tissues. Epoxyoleic acid was shown
to be present as a mixture of predominately monovernoloyl triglycerides with some divernoloyl triglycerides and small amounts
of trivernolin. Lipase hydrolysis of the first two triglycerides has demonstrated that the vernoloyl groups are present mostly
in the 1,3 positions. In a separate experiment, rats were fed cholesterol epoxide at the 0.5% and 1.5% levels in the diet
for 90 days. TLC and GLC examination of lipids from these rats failed to reveal the presence of any cholesterol epoxide. Only
one-half of the sterol fed could be accounted for in the fecal lipids.
Presented in part at the AOCS Meeting, Chicago, October 1967. |
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