A special fluorescent in situ hybridization technique to study peripheral blood and assess the effectiveness of interferon therapy in chronic myeloid leukemia |
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| Authors: | I Bu?o WA Wyatt AR Zinsmeister J Dietz-Band RT Silver GW Dewald |
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| Affiliation: | Division of Laboratory Genetics and Section of Biostatistics, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. |
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| Abstract: | Using a highly sensitive fluorescence in situ hybridization method with probes for BCR and ABL1 (D-FISH), we studied 37 paired sets of bone marrow and blood specimens, collected within 24 to 96 hours of each other, from 10 patients before and during treatment for chronic myeloid leukemia (CML). The normal range for 500 interphase nuclei was
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