(1) Laboratoire de Biochimie Médicale A, Université de Bordeaux 11, 146, rue Léo-Saignat, 33076 Bordeaux-Cédex, France;(2) Present address: C.N.R.S., Centre de Neurochimie du, 11 rue Humann, 67085 Strasbourg-Cédex, France
Abstract:
We have studied the fatty acid composition of total phosphoglycerides from various types of nerve cells in culture. Primary
cell cultures were compared with tumoral cell strains. Glial cells exhibited no characteristic pattern when compared to neurons.
Tumoral cell phosphogly cerides contained much higher levels of octadecenoic acid and lower levels of C-20 to C-22 polyunsaturated
fatty acids than normal cell phosphoglycerides. This observation seems to be a general feature in tumoral cell membranes.
It could be of interest in respect to the membrane fluidity of cancer cells.