| 一种新型靶向壳聚糖纳米载体的制备及性质 |
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| 引用本文： | 李彦艳,张闪闪,柳峰松,张瑞英. 一种新型靶向壳聚糖纳米载体的制备及性质[J]. 应用化工, 2014, 0(7): 1214-1217 |
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| 作者姓名： | 李彦艳 张闪闪 柳峰松 张瑞英 |
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| 作者单位： | 河北大学生命科学学院; |
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| 基金项目： | 河北省自然科学基金-石药集团医药联合研究基金(CSPC,E2013201205);河北省高等学校科学技术研究青年基金项目(Q2012140);2014年保定市科学技术研究与发展指导计划(14ZF052) |
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| 摘 要： | 制备了不同乳糖取代度的乳糖化油酰壳聚糖(Lac-OCH)。通过粘度法检测了Lac-OCH的流变学特性;通过荧光法研究了Lac-OCH在溶液中的自聚集行为,随着乳糖取代度升高,临界聚集浓度(CAC)值升高;采用超声法制备Lac-OCS纳米体系;采用透射电镜观察Lac-OCH纳米球呈现椭球棒状,粒径约为200 nm;研究了Lac-OCH负载药物阿霉素后的包封率和体外释放情况。
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| 关 键 词： | 乳糖化油酰壳聚糖 纳米微球 阿霉素 体外释放 |
Preparation and properties of novel drug-loaded targeting chitosan nanoparticles |
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| LI Yan-yan;ZHANG Shan-shan;LIU Feng-song;ZHANG Rui-ying. Preparation and properties of novel drug-loaded targeting chitosan nanoparticles[J]. Applied chemical industry, 2014, 0(7): 1214-1217 |
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| Authors: | LI Yan-yan ZHANG Shan-shan LIU Feng-song ZHANG Rui-ying |
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| Affiliation: | LI Yan-yan;ZHANG Shan-shan;LIU Feng-song;ZHANG Rui-ying;College of Life Science,Hebei University; |
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| Abstract: | The lactose-oleoylchitosan（ Lac-OCH ）with different degree of substitution（ DS ）of lactose was PrePared. The rheological features of Lac-OCH were investigated by viscosity assay. The CAC value in-creased along with the increase of DS of lactose. The Lac-OCH nanoParticles showed dense,axiolitic tex-ture and the average diameter was aPProximate 200 nm. The sustained-release characteristics of Lac-OCH nanoParticles were studied using doxorubicin（ DOX）as model drug. The results revealed the Promising Po-tential of amPhiPhilic Lac-OCH as drug carrier. |
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| Keywords: | lactose-oleoylchitosan nanoParticles doxorubicin drug delivery system |
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