Accuracy of centrally recorded OPCS codes for vascular surgery in the United Kingdom |
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Authors: | RB Galland TR Magee DC Berridge GB Hopkinson MH Lewis S Shiralkar SD Parvin |
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Affiliation: | Faculty of Pharmaceutical Sciences, Chiba University, Japan. |
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Abstract: | Five (20S)-10-hydroxycamptothecin derivatives carrying the long-chain fatty acid esters were prepared for the development of a new class of prodrug-type agents. In vitro experiments using three kinds of purified carboxylesterase isozymes from the liver microsomes of rat, pig, and human demonstrated that these derivatives were efficiently metabolized by enzymes compared with CPT-11. |
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