| 2-溴噻唑-4-甲酸合成方法的改进 |
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| 引用本文： | 张秀芹,杨晓云,杨真锐,周琢强.2-溴噻唑-4-甲酸合成方法的改进[J].广州化工,2009,37(2):94-95. |
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| 作者姓名： | 张秀芹 杨晓云 杨真锐 周琢强 |
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| 作者单位： | 华南农业大学理学院,广东,广州,510642 |
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| 摘 要： | 以硫脲为原料、溴代丙酮酸乙酯为试剂，无溶剂合成出2-氨基噻唑-4-甲酸乙酯，随后经DMSO、亚硝酸钠高温重氮化法得到2-溴噻唑-4-甲酸乙酯，最后经碳酸钾-甲醇溶液皂化得到目标2-溴噻唑-4-甲酸。各步化合物经熔点、高效液相、质谱、氢核磁谱等分析手段，验证结构符合及纯度。
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| 关 键 词： | 2-溴噻唑-4-甲酸 无溶剂 重氮化 皂化 |
Improved Method for Synthesis of 2-Bromo-Thiazole- 4-Carboxylic Acid |
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| ZHANG Xiu-qin,YANG Xiao-yun,YANG Zhen-rui,ZHOU Zhuo-qiang.Improved Method for Synthesis of 2-Bromo-Thiazole- 4-Carboxylic Acid[J].GuangZhou Chemical Industry and Technology,2009,37(2):94-95. |
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| Authors: | ZHANG Xiu-qin YANG Xiao-yun YANG Zhen-rui ZHOU Zhuo-qiang |
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| Affiliation: | College of Science;South China Agricultural University;Guangdong Guangzhou 510642;China |
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| Abstract: | Ethyl 2-amino-thiazole-4-carboxylate was synthesized with thiourea and ethyl bromopyruvate by solvent-free.Then it was reacted with DMSO and sodium nitrite by diazotization in high temperature to form ethyl 2-bromothiazole-4-carboxylate.Finally,the 2-bromo-thiazole-4-carboxy acid was synthesized by ethyl 2-bromothiazole-4-carboxylate through saponification in potash-methanol solvent.The compounds were determined by means of melting point measurement,IR,MS(ESI),1H-NMR.The result showed exact structure and pu... |
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| Keywords: | 2-bromo-thiazole-4-carboxylic acid solvent-free diazotization saponification |
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