Voltammetric determination of bisoprolol fumarate in pharmaceutical formulations and urine using single-wall carbon nanotubes modified glassy carbon electrode |
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Authors: | Rajendra N Goyal Anuradha Tyagi Sunita Bishnoi |
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Affiliation: | a Department of chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India b Amity Institute of Nanotechnology, Amity University, Noida 201301, India |
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Abstract: | The electrochemistry of bisoprolol fumarate (BF) has been investigated by differential pulse voltammetry at a single-wall carbon nanotubes (SWNTs) modified glassy carbon electrode (GCE). The prepared electrode showed an excellent electrocatalytic activity towards the oxidation of BF leading to a marked improvement in sensitivity as compared to bare glassy carbon electrode where electrochemical activity for the analyte cannot be observed. The SWNTs-modified GCE exhibited a sharp anodic peak at a potential of ∼950 mV for the oxidation of BF. Under optimum conditions linear calibration curve was obtained over the BF concentration range 0.01-0.1 mM in 0.5 M phosphate buffer solution (pH 7.2) with a correlation coefficient of 0.9789 and detection limit of 8.27 × 10−7 M. The modified electrode has been applied for the drug determination in human urine with no prior extraction and in commercial tablets. The proposed method has also been validated. |
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Keywords: | Single-wall carbon nanotubes Bisoprolol fumarate Urine Differential pulse voltammetry |
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