Electrocatalytic oxidation of deferiprone and its determination on a carbon nanotube-modified glassy carbon electrode |
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Authors: | H Yadegari H Heli K Karimian |
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Affiliation: | a Department of Chemistry, Faculty of Science, K.N. Toosi University of Technology, P.O. Box 16315-1618, Tehran, Iran b Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran c Arasto Pharmaceutical Chemicals Inc., Tehran, Iran d Department of Chemical Engineering, Faculty of Engineering, University of Tehran, Tehran, Iran |
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Abstract: | The electrochemical behavior of the anti-thalassemia and anti-HIV replication drug, deferiprone, was investigated on a carbon nanotube-modified glassy carbon (GC-CNT) electrode in phosphate buffer solution, pH 7.40 (PBS). During oxidation of deferiprone, two irreversible anodic peaks, with and , appeared, using GC-CNT. Cyclic voltammetric study indicated that the oxidation process is irreversible and diffusion controlled. The number of exchanged electrons in the electro-oxidation process was obtained, and the data indicated that deferiprone is oxidized via two two-electron steps. The results revealed that carbon nanotube (CNT) promotes the rate of oxidation by increasing the peak current, so that deferiprone is oxidized at lower potentials, which thermodynamically is more favorable. This result was confirmed by impedance measurements. The diffusion coefficient, electron-transfer coefficient and heterogeneous electron-transfer rate constant of deferiprone were found to be 1.49 × 10−6 cm2 s−1, 0.44, and 3.83 × 10−3 cm s−1, respectively. A sensitive, simple and time-saving differential-pulse voltammetric procedure was developed for the analysis of deferiprone. Using the proposed method, deferiprone can be determined with a detection limit of 5.25 × 10−7 M. The applicability of the method to direct assays of spiked human serum and urine fluids is described. |
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Keywords: | Carbon nanotube Modified electrode Deferiprone Anti-thalassaemia drug Electrocatalysis HIV-1 replication inhibitor |
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