Anticonvulsant activity of furanocoumarins and the essential oil obtained from the fruits of Heracleum crenatifolium |
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Authors: | Fatma Tosun,Ç iğdem Akyü z Kızılay,Kevser Erol,Fatma Sultan Kılıç ,Mine Kü rkç ü oğlu,Kemal Hü snü Can Başer |
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Affiliation: | 1. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara, Turkey;2. Department of Pharmacology, Faculty of Medicine, Eski?ehir Osmangazi University, 26480 Eski?ehir, Turkey;3. Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eski?ehir, Turkey |
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Abstract: | The anticonvulsant activity of furanocoumarins, coumarin mixture and the essential oil obtained from the fruits of Heracleum crenatifolium was examined against maximal electroshock (MES)-induced seizures in mice. Bergapten showed significant anticonvulsant activity. The furanocoumarins isolated from the fruits of the plant were identified using thin-layer chromatography, melting points and spectroscopic methods (IR, MS, 1H NMR) as isobergapten (1), pimpinellin (2), bergapten (3), isopimpinellin (4), sphondin (5) and byak-angelicol (6). The essential oil content of the fruits were found as 5.5%. Twenty-two compounds representing 99.3% of the essential oil obtained from the fruits of H. crenatifolium were determined and the major components were identified as octanol and octyl acetate (3.1% and 88.4% respectively) by GC and GC–MS. |
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Keywords: | Heracleum crenatifolium Furanocoumarin Essential oil Anticonvulsant MES |
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