Selective solid-phase extraction using molecular imprinted polymer for the analysis of diethylstilbestrol |
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Authors: | Xiaoman Jiang Chuande ZhaoNa Jiang Haixia ZhangMancang Liu |
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Affiliation: | College of Chemistry and Chemical Engineering, Lanzhou University, No. 222 Tianshui Road, Lanzhou, Gansu 730000, PR China |
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Abstract: | A simple imprinted amino-functionalized silica gel material was synthesized by combining a surface molecular imprinting technique with a sol–gel process for solid-phase extraction–high performance liquid chromatography (SPE–HPLC) determination of diethylstilbestrol (DES). Activated silica gel was used as the supporter and non-imprinted silica sorbent was synthesized without the addition of DES using the same procedure as that of DES-imprinted silica sorbent. Compared with non-imprinted polymer particles, the prepared DES-imprinted silica sorbent showed high adsorption capacity, significant selectivity, good site accessibility and fast binding kinetics for DES. The maximum static adsorption capacity of the DES-imprinted and non-imprinted silica sorbent for DES was 62.58 mg g−1 and 19.89 mg g−1, respectively. The relatively selective factor value of this DES-imprinted silica sorbent was 61.7 at the level of 50 mg L−1. And the uptake kinetics was fairly rapid so that the adsorbent equilibrium was achieved within 10 min. Furthermore, the DES-imprinted polymers were used as the sorbent in solid-phase extraction to determine DES in fish samples. The MIP–SPE–HPLC method showed higher selectivity and good recoveries higher than 87.5% (R.S.D. 11.6%). |
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Keywords: | Molecularly imprinted polymers Surface imprinted technique Diethylstilbestrol Solid-phase extraction High performance liquid chromatography |
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