| 液相色谱-串联质谱检测兽药残留中的基质效应研究进展 |
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| 引用本文： | 王立琦,贺利民,曾振灵,陈建新.液相色谱-串联质谱检测兽药残留中的基质效应研究进展[J].质谱学报,2011,32(6):321-332. |
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| 作者姓名： | 王立琦 贺利民 曾振灵 陈建新 |
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| 作者单位： | 华南农业大学兽医学院，兽医药理研究室，广东 广州510642 |
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| 基金项目： | 国家自然科学基金项目(No.31072166)资助 |
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| 摘 要： | 液相色谱-串联质谱技术作为强有力的分析工具已被广泛应用于多个领域，但其检测中的基质效应对测定结果准确性的影响需引起重视。本文综述了液相色谱-串联质谱分析测定中基质效应的来源、重要性、产生的可能机制、影响因素、评价及消除和（或）补偿基质效应的方法，重点概括了典型兽药残留检测中应对基质效应的方法进展。
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| 关 键 词： | 液相色谱-串联质谱 基质效应 机制 影响因素 兽药残留 消除方法 |
Progress in Matrix Effect of Veterinary Drug Residues Analysis by High-Performance Liquid Chromatography Tandem Mass Spectrometry |
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| WANG Li-qi,HE Li-min,ZENG Zhen-ling,CHEN Jian-xin.Progress in Matrix Effect of Veterinary Drug Residues Analysis by High-Performance Liquid Chromatography Tandem Mass Spectrometry[J].Journal of Chinese Mass Spectrometry Society,2011,32(6):321-332. |
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| Authors: | WANG Li-qi HE Li-min ZENG Zhen-ling CHEN Jian-xin |
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| Affiliation: | Department of Veterinary Pharmacology and Toxicology,College of Veterinary Medicine, South China Agricultural University, Guangzhou 510642, China |
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| Abstract: | High-performance liquid chromatography tandem mass spectrometry(LC-MS/MS) is a powerful analytical tool which has been applied to a wide variety of studies.One limitation associated with LC-MS/MS analysis is its susceptibility to matrix effect,which should be paid attention.In the present paper,the sources,importance,proposed mechanism,factors,evaluation,eliminating and(or) compensating means of matrix effect in LC-ESI-MS/MS analysis are reviewed,and especially,progress in dealing with matrix effect in typi... |
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| Keywords: | high-performance liquid chromatography tandem mass spectrometry matrix effect mechanism factors veterinary drug residues elimination |
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