| 碘普罗胺合成路线图解 |
| |
| 引用本文： | 赵文龙.碘普罗胺合成路线图解[J].淮海工学院学报,2013,22(3):50-52. |
| |
| 作者姓名： | 赵文龙 |
| |
| 作者单位： | 江苏正大天晴药业股份有限公司,江苏连云港,222000 |
| |
| 摘 要： | 对广泛应用的非离子型造影剂碘普罗胺的合成路线进行了综合论述，依据原料的不同可以归结为两类合成方法：以5-氨基-2，4，6-三碘异酞酸及其衍生物为原料，经过酰化引入氨基甘油和甲基氨基甘油；以间硝基苯二甲酸及其酯化衍生物为原料，经过酰化、芳环碘代合成碘普罗胺。
|
| 关 键 词： | 碘普罗胺 碘造影荆 合成路线图解 |
Graphical Synthetic Routes of Iopromide |
| |
| ZHAO Wen-long.Graphical Synthetic Routes of Iopromide[J].Journal of Huaihai Institute of Technology:Natural Sciences Edition,2013,22(3):50-52. |
| |
| Authors: | ZHAO Wen-long |
| |
| Affiliation: | ZHAO Wen-long (Chia-tai Tianqing Pharmaceutical Co. , Ltd. , Lianyungang 222000, China) |
| |
| Abstract: | Graphical synthetic routes of iopromide were summarized in this paper. These kinds of methods could be divided into two main groups on the basis of different starting material： the in- troduction of amino glycerin and methyl amino glycerin through acylation of 5-amine-2,4,6-triio-do isophthalic acid and its derivatives, and the acylation and iodination of 3-Nitro isophthalic acid and its derivatives to give iopromide. Both methods have their own advantages in the production. |
| |
| Keywords: | iopromide diodone graphical synthetic routes |
| 本文献已被 维普 万方数据 等数据库收录！ |
