On-chip whole blood plasma separator based on microfiltration,sedimentation and wetting contrast |
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Authors: | Sanghoon Park Roxana Shabani Mark Schumacher Yoon-Seoung Kim Young Min Bae Kyeong-Hee Lee Hyoung Jin Cho |
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Affiliation: | 1.Mechanical and Aerospace Engineering,University of Central Florida,Orlando,USA;2.Burnett School of Biomedical Sciences, College of Medicine,University of Central Florida,Orlando,USA;3.Korea Electrotechnology Research Institute,Ansan,Republic of Korea |
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Abstract: | Miniaturized on-chip blood separators have a great value for point-of-care diagnosis. In our work, a combined design strategy—microfiltration, sedimentation in a retarded flow, and wetting contrast—was taken to overcome the known limitations of on-chip blood separators. Our microfluidic chip consists of a polydimethylsiloxane micropillar array and an etched glass with microchannel branches. The red blood cells are significantly slowed and gradually settled down due to micropillars and enlarged dimension of a chamber. An etched glass microchannel allows the extraction of blood plasma exclusively due to the capillary effect. The fabricated microfluidic device can separate blood plasma from a whole blood sample without any external driving force or dilution. The measured plasma separation efficiency was close to 100 % from human whole blood. Autonomous on-chip separation and collection of blood plasma was demonstrated. |
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