Influence of some aromatic amino acids on the swelling behavior of acrylamide/maleic acid hydrogel |
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Authors: | H Nursevin Öztop Dursun Sarayd?n Erdener Karada? Yasemin Çald?ran Olgun Güven |
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Affiliation: | (1) Department of Chemistry, Cumhuriyet University, TR-58140 Sivas, Turkey, TR;(2) Department of Chemistry, Adnan Menderes University, TR-09010 Aydın, Turkey, TR;(3) Department of Chemistry, Hacettepe University, TR-06532 Beytepe, Ankara, Turkey, TR |
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Abstract: | Summary
Influence of some aromatic amino acids (histidine, phenylalanine and tryptophan) on the swelling behavior of acrylamide/maleic
acid hydrogel (AAm/MA) prepared by γ-radiation was investigated. Swelling tests of AAm/MA hydrogel were made in buffer solutions
and amino acid solutions at various pH at 37°C. The pH values are ionization of α-carboxyl groups (pK'1), α-amino groups (pK'2) and, isoelectric points (pI) of amino acids. The swelling of AAm/MA hydrogel increased when pH values of solutions were
increased. The value of equilibrium swelling of AAm/MA hydrogel was 1035% at pH 10 buffer, while it was 880% at pH 2 buffer.
The values of equilibrium swelling of AAm/MA hydrogel in phenylalanine, tryptophan and histidine solutions varied among 1130–1245%
at pH 10, while they were among 790–975% at pH 2. The rate constant of swelling, diffusional exponent, network parameter and,
diffusion and intrinsic diffusion coefficient were calculated by swelling kinetics. Diffusion of the penetrants into the hydrogel
was found to be non-Fickian character. The diffusion coefficients of the hydrogel varied between 3.33×10−6– 7.71×10−6 cm 2s−1, while the intrinsic diffusion coefficients waried between 4.03×10−6– 8.48×10−6 cm 2s−1.
Received: 22 December 1997/Revised version: 3 March 1998/Accepted: 5 March 1998 |
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