Tacrolimus therapy for persistent or recurrent acute rejection after lung transplantation |
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Authors: | NR Horning JP Lynch SR Sundaresan GA Patterson EP Trulock |
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Affiliation: | Centre for Applied Microbiology and Research (CAMR), Salisbury, Wiltshire, UK. |
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Abstract: | Purified native F1 antigen from Yersinia pestis was used to assess controlled-release vaccine delivery systems in poly(lactide-co-glycolide) (PLG) microparticles and liposomes. Antigen encapsulated in PLG microparticles induced high serum titres when injected i.p. in mice: mucosal IgA was also detected. Mice immunized with F1 in Alhydrogel or PLGs were protected against subcutaneous challenge with Y. pestis. F1 antigen surface-labelled onto liposome vesicles stimulated high serum titres in Balb/c mice and also induced a mucosal response: F1-labelled liposomes protected mice against challenge with up to 1 x 10(5) organisms. These findings indicate that a significant immune response is induced by immunizing with F1 formulated in PLGs and liposomes and that protection was achieved after only one dose. |
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