Unc-1: a stomatin homologue controls sensitivity to volatile anesthetics in Caenorhabditis elegans |
| |
Authors: | S Rajaram MM Sedensky PG Morgan |
| |
Affiliation: | Departments of Anesthesiology and Genetics, University Hospitals, Case Western Reserve University, Cleveland, OH 44106, USA. |
| |
Abstract: | To identify sites of action of volatile anesthetics, we are studying genes in a functional pathway that controls sensitivity to volatile anesthetics in the nematode Caenorhabditis elegans. The unc-1 gene occupies a central position in this pathway. Different alleles of unc-1 have unique effects on sensitivity to the different volatile anesthetics. UNC-1 shows extensive homology to human stomatin, an integral membrane protein thought to regulate an associated ion channel. We postulate that UNC-1 has a direct effect on anesthetic sensitivity in C. elegans and may represent a molecular target for volatile anesthetics. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|