| 吡拉西坦缓释固体分散体的制备及体外溶出度研究 |
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| 引用本文： | 王洁,金刚,薛健飞,曲小姝,张燕,展瑞岩.吡拉西坦缓释固体分散体的制备及体外溶出度研究[J].吉林化工学院学报,2014,31(11):25-27. |
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| 作者姓名： | 王洁 金刚 薛健飞 曲小姝 张燕 展瑞岩 |
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| 作者单位： | 吉林化工学院化学与制药工程学院,吉林吉林,132022 |
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| 摘 要： | 目的:采用溶剂-冷冻干燥法制备吡拉西坦(Piracetam)缓释固体分散体(SD)来减缓药物的释放速度.方法:分别选用乙基纤维素(EC)、羟丙甲基纤维素(HPMC)及甲基纤维素(MC)为载体制备吡拉西坦固体分散体,以体外溶出度为考查指标,选择最优载体.结果:当选用EC与HPMC的混合物为载体,且药物:EC HPMC的比例为1 3 0.7时,在2、6、12 h累计溶出度分别达到了30%、50%、80%左右,由此可见,将吡拉西坦制成固体分散体可起到很好的缓释效果.
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| 关 键 词： | 吡拉西坦 缓释 固体分散体 体外溶出度 |
Research on Preparation and in Vitro Dissolution Rate of the Sustained Release Solid Dispersions of Piracetam |
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| WANG Jie
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JIN Gang
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XUE Jian-fei
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QU Xiao-shu
,
ZHANG Yan
,
ZHAN Rui-yan.Research on Preparation and in Vitro Dissolution Rate of the Sustained Release Solid Dispersions of Piracetam[J].Journal of Jilin Institute of Chemical Technology,2014,31(11):25-27. |
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| Authors: | WANG Jie JIN Gang XUE Jian-fei QU Xiao-shu ZHANG Yan ZHAN Rui-yan |
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| Affiliation: | WANG Jie;JIN Gang;XUE Jian-fei;QU Xiao-shu;ZHANG Yan;ZHAN Rui-yan;College of Chemical and Pharmaceutical Engineering,Jilin Institute of Chemical Technology; |
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| Abstract: | OBJECTIVE：Preparing the sustained release solid dispersions of piracetam to slow down the dissolution rate by the solvent-freeze drying method. METHODS： Selecting the optimal carriers from EC HPMC ,MC with the dissolution rate values. CONCLUSION ：When using the mixture of EC and HPMC as the carrier, the dissolution rate of the solid dispersion was 30% ,50% ,80% at 2,6,12 h, it had a better sustained release effect. |
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| Keywords: | piracetam sustained release solid dispersion in vitro dissolution |
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