Selective impairment of long-term but not short-term conditional fear by the N-methyl-D-aspartate antagonist APV. |
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Authors: | Kim, Jeansok J. Fanselow, Michael S. DeCola, Joseph P. Landeira-Fernandez, Jesus |
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Abstract: | Previous research has indicated that the competitive N-methyl-D-aspartate (NMDA) antagonist APV ({dl}-2-amino-5-phosphonovalerate) prevents the Pavlovian conditioning of fear to contextual stimuli when tested 24 hrs, but not immediately, after training. The present study investigated this differential time-dependent effect of APV on fear conditioning. Rats were given either APV or saline and presented with 3 footshocks in a distinctive chamber. Promptly after the shock, rats that had received APV exhibited a species-typical fear response: freezing. However, the freezing lasted for only a short period of time ( |
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