诺氟沙星柱撑水滑石抗生素药物体外释放性能的研究

采用共沉淀法，以Mg2A1-N0，-LDHs为主体，利用水滑石层问阴离子的可交换性，通过离子交换法合成诺氟沙星柱撑水滑石。讨论了诺氟沙星柱撑水滑石在不同pH值条件下的体外释放效果。采用FT／IR、XRD、SEM技术对产物的结构进行了表征，采用TG-DSC技术对产物的热稳定性进行研究，同时通过紫外一可见分光光度计和片剂四用测定仪检测其体外释放效果。诺氟沙星阴离子被插入水滑石层间，其在pH=8．4时有较好的释放效果。结果表明，水滑石是很好的药物载体。

Study on drug-antibiotic in vitro release of norfloxacin pillared layered double hydroxides SHEN Ai-min, LIU Cui-juan, TONG De-cheng, ZHANG Lei,

A drug-inorganic composite involving an norfloxacin intercalated Mg-Al layered double hydroxides was prepared with coprecipitation and ion-exchange methods. Mg2A1-NO3-LDHs were prepared by coprecipitation methods. Norfloxacin pillared hyarotalcite was synthetized by ion exchange method with Mg2A1-NO3-LDHs as raw materials. The structures of products were characterized by FT/IR, XRD and SEM, the thermal stability was characterized by TG-DSC, and in vitro release behavior was studied by UV spectrophotometer and tablet four-detector. The results show that norfloxacin anion had been inserted into hydrotalcite layers, and it has a better in vitro release behavior at pH=8.4. It has a good invitro release effect when norfloxacin is inserted into LDHs which is a good drug carrier.