| LC-MS/MS鉴定阿齐沙坦降解产物 |
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| 引用本文： | 吴强,陈金嫚,何广卫.LC-MS/MS鉴定阿齐沙坦降解产物[J].广州化工,2014(19):105-107. |
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| 作者姓名： | 吴强 陈金嫚 何广卫 |
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| 作者单位： | 1. 合肥医工医药有限公司,安徽 合肥,230601
2. 广州博腾生物医药科技有限公司,广东 广州,510663 |
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| 摘 要： | 以1%甲酸溶液-乙腈为流动相,经C18柱（250 mm×4.6 mm,5μm）分离,通过串联ESI质谱在线检测,获得相关的色谱和质谱信息。根据研究结果推测光降解主要产物为1-（（2＇-1H-双吖丙啶-3-基-1,1＇-联苯]-4-基）甲基）-2-乙氧基-1H-苯并d]咪唑-7-羧酸,酸降解主要产物为2-氧代-3-（（2＇-（5-氧代-4,5-二氢-1,2,4-噁二唑酮-3-基）-1,1＇-联苯]-4-基）甲基）-2,3-二氢-1H-苯并d]咪唑-4-羧酸。
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| 关 键 词： | 阿齐沙坦 降解产物 高效液相色谱-串联质谱 |
Identification of the Degradation Compounds of Azilsartan by LC-MS |
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| WU Qiang,CHEN Jin-man,HE Guang-wei.Identification of the Degradation Compounds of Azilsartan by LC-MS[J].GuangZhou Chemical Industry and Technology,2014(19):105-107. |
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| Authors: | WU Qiang CHEN Jin-man HE Guang-wei |
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| Affiliation: | WU Qiang;CHEN Jin-man;HE Guang-wei;Hefei Industrial Pharmaceutical Institute Co.,Ltd.;Guangzhou Botten Biological Pharmaceutical Technology Co.,Ltd.; |
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| Abstract: | The HPLC separation experiment.~ were performed on a C ls column （250 mm × 4.6 mm, 5 μm）, with 1% formic acid - acetonitrile as mobile phase. The analytics were determined by ESI - MS. The chromatograms and mass spectra of forced degradation products of azilsartan were obtained by LC - MS. The structure of impurities were confirmed as 1 - （ （2＇- （ 1H - diazirin - 3 - yl） - 1,1＇- biphenyl ] - 4 - yl） methyl） - 2 - ethoxy - 1H - benzo d ] imidazole - 7 - carboxylic acid, 2 - oxo - 3 - （ （ 2＇- （5 - 020 - 4,5 - dihydro - 1,2,4 - oxadiazol - 3 - yl ） - 1,1＇- biphenyl ] - 4 - yl） methyl） - 2,3 - dihydro - 1H - benzo d ] imidazole - 4 - carboxylic acid, respectively. |
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| Keywords: | azilsartan degradation compounds LC-MS |
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