| HPLC法测定替加氟氯化钠注射液的含量 |
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| 引用本文： | 唐杨,李艳,程辉跃,张伟,王益平.HPLC法测定替加氟氯化钠注射液的含量[J].广州化工,2014(19):111-112,137. |
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| 作者姓名： | 唐杨 李艳 程辉跃 张伟 王益平 |
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| 作者单位： | 重庆市食品药品检验所，重庆市药物过程与质量控制工程技术研究中心，重庆 401121 |
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| 摘 要： | 建立了用HPLC法测定替加氟氯化钠注射液的含量的方法。采用sunfire TM C185μm 4.6×250 mm色谱柱,流动相：甲醇-乙腈-水（10∶5∶85）,流速：1.0 mL·min-1,检测波长：271 nm,柱温：30℃。结果显示：替加氟进样量在10.64~4 256 ng范围内线性良好（r=1.0000）,平均回收率为100.1%（n=9）,RSD为0.65%。该方法简便、专属、准确,可用于替加氟氯化钠注射液中替加氟的含量测定。
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| 关 键 词： | 高效液相色谱法 替加氟氯化钠注射液 替加氟 含量测定 |
Determination of Tegafur and Sodium Chloride Injection by HPLC |
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| TANG Yang,LI Yan,CHENG Hui-yue,ZHANG Wei,WANG Yi-ping.Determination of Tegafur and Sodium Chloride Injection by HPLC[J].GuangZhou Chemical Industry and Technology,2014(19):111-112,137. |
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| Authors: | TANG Yang LI Yan CHENG Hui-yue ZHANG Wei WANG Yi-ping |
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| Affiliation: | TANG Yang;LI Yan;CHENG Hui-yue;ZHANG Wei;WANG Yi-ping;Chongqing Institute for Food and Drug Control,Chongqing Engineering Research Center for Pharmaceutical Process and Quality Control; |
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| Abstract: | The HPLC method for determination of tegafur and sodium chloride injection was established. Sunfire TM Cls 5 μm 4. 6 ×250 mm column was used. The mobile phase was methol -acetonitrile -water （10 ： 5 ： 85） with a flow rate of 1.0 mL · min -1 The detection wavelength was set at 271 nm. The column temperature was 30 ℃. The calibration curve of tegafur showed a good linearity at 10. 64 ~4 256 ng （ r = 1. 0000 ）, and the average recovery was 100. 1% （ n = 9 ）, RSD = 0. 65%. This method was simple, specific and accurate for determination of tegafur and sodium chloride injection. |
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| Keywords: | HPLC tegafur and sodium chloride injection tegafur determination |
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