转移性乳腺癌患者血清 CA15-3和 CEA 水平与临床病理参数的关系

目的：探讨转移性乳腺癌患者血清糖类抗原15-3（CA15-3）和癌胚抗原（CEA）水平与临床病理参数的关系。方法收集2007年1月至2012年12月皖南医学院第一附属医院收治的转移性乳腺癌患者284例，所有患者在诊断为转移性乳腺癌时，均检测血清 CA15-3和 CEA 水平，统计分析血清 CA15-3和 CEA 水平与患者临床病理参数的关系。结果284例患者中，血清 CA15-3高于正常水平者163例（57．4％），血清 CEA 高于正常水平者97例（34．2％）。血清 CA15-3和 CEA 水平升高与乳腺癌分子分型有关（均 P ＜0．05）。Luminal 亚型患者血清 CA15-3和CEA 升高比例显著高于 HER2-enriched 亚型及 TN 亚型。血清 CA15-3升高与骨转移有关（P ＜0．05），而血清CEA 升高与转移部位无关。多处转移的患者血清 CA15-3升高比例高于单处转移的患者（P ＜0．05），而血清 CEA升高比例在单处转移的患者和多处转移的患者无明显差异（P ＞0．05）。结论转移性乳腺癌患者中，CA15-3、CEA 升高与乳腺癌分子亚型显著相关，骨转移的患者 CA15-3升高比例高于其他转移部位，而 CEA 升高与转移部位无关。多处转移的患者 CA15-3升高比例高于单处转移的患者。

Relationships of Serum CA15-3 and CEA levels to Clinicopathological Parameters in Patients with Metastatic Breast Cancer

Objective To investigate the relationships between serum carbohydrate antigen 15-3（CA15-3）and carcinoembryonic antigen（CEA）levels and clinicopathological parameters in pa-tients with metastatic breast cancer（MBC）.Methods Data of 284 MBC patients treated in the First Affiliated Hospital of Wannan Medical College between January 2007 and December 2012 were collected.Serum CA15-3 and CEA levels were measured when they were diagnosed as having MBC.The relationships between serum CA15-3 and CEA levels and clinicopathological parame-ters were analyzed.Results Of the 284 patients,elevated serum CA15-3 and CEA levels were i-dentified in 163（57.4%）and 97（34.2%）,respectively.The elevated serum CA15-3 and CEA lev-els were significantly associated with breast cancer molecular subtypes（P 〈0.05）.The percentage of patients with elevated serum CA15-3 and CEA levels among patients with luminal subtypes was higher than that among patients with HER2-enriched and TN subtypes.The elevated serum CA15-3 levels were correlated with bone metastasis（P 〈0.05）.However,the elevated serum CEA levels were not correlated with the sites of metastasis.The percentage of patients with elevated serum CA15-3 levels among patients with multiple metastases was higher than that among pa-tients with single metastasis（P 〈0.05）.There was no significant difference in the incidence of se-rum CEA elevation between patients with single metastasis and patients with multiple metastases （P 〉0.05）.Conclusion The elevated CA15-3 and CEA levels are associated with breast cancer molecular subtypes in patients with MBC.The percentage of patients with elevated serum CA15-3 levels among patients with bone metastasis is higher than that among patients with other metasta-sis,and that among patients with multiple metastases is higher than that among patients with sin-gle metastasis.The elevated CEA levels are not correlated with the sites of metastases.