膜乳化技术-复乳法制备载药微囊的研究

以乙交酯和丙交酯的无规共聚物(PLGA)做为包埋材料,采用膜乳化技术结合复乳溶剂挥发法制备BSA载药微囊。研究了膜乳化压力、搅拌速度和固化时间对包封率的影响,以及载药微囊的体外释放行为。分析表明,随着膜乳化压力的增加,包封率会不同程度的降低;当搅拌速度大于200 rpm时,搅拌速度的增加也会导致包封率的降低;固化时间为5h时,包封率最高。采用膜乳化技术,可以有效的缓解载药微囊的突释现象,1个月内的累计释放量可以达到80%以上。

Preparation of Microcapsules by Combining Shirasu Porous Glass(SPG)Membrane Emulsification and Multiple Emulsion-solvent Evaporation Method

BSA -loaded microcapsules were prepared by combining Shirasu Porous Glass （SPG） membrane emulsification technique and multiple emulsion - solvent evaporation method with poly （ lactic - co - glycolic acid） （PLGA） as the carrier material. The effect of press, stirrer speed and solidification time on encapsulation efficiency and the release behavior of BSA -loaded microcapsules were investigated. It was demonstrated that the encapsulation efficiency reduced when press was increased, when stirrer speed was more than 200rpm, the encapsulation efficiency also reduced by the increase of stirrer speed, and the encapsulation efficiency was the highest when solidification time was 5h. Initial release was lower when microcapsules were prepared by SPG membrane emulsification technique, and the total release achieved 80% in a month.