Physics of Open Systems: Effects of the Impact of Chemical Stressors on Differential Gene Expression |
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| Authors: | V. O. Ageev T. L. Kachanova L. Kopylev M. Spassova B. F. Fomin O. B. Fomin Chen W. Chao |
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| Affiliation: | 1. St. Petersburg Electrotechnical University “LETI”, St. Petersburg, Russia
2. United States Environmental Protection Agency, Washington, USA
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| Abstract: | The technologies of the physics of open systems are applied to generate the systemic knowledge about variations in gene activity under the impact of chemical stressors. The system knowledge is automatically generated based on the genomic data obtained by using the microarray technology. The system knowledge has been used for scientific understanding and rational explanation of regular changes in gene activity depending on the biomaterial sample, type of the chemical and its concentration, and time series of experiments. |
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