| 脑功能显像剂99Tcm-Memantine的初步研究 |
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| 引用本文： | 张建康,周杏琴,颜成龙,徐希杰,曹国宪.脑功能显像剂99Tcm-Memantine的初步研究[J].同位素,2008,21(4). |
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| 作者姓名： | 张建康 周杏琴 颜成龙 徐希杰 曹国宪 |
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| 作者单位： | 1. 江苏省原子医学研究所,江苏,无锡,214063
2. 江南大学,医药学院,江苏,无锡,214122 |
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| 基金项目： | 国家自然科学基金项目
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江苏省卫生厅重大项目
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| 摘 要： | 用~(99)Tc~m标记N-2-(N-(2-巯基乙基))氨基甲酰甲基]-N-(2-巯基乙基)-3,5-二甲基金刚烷胺基乙酰胺(N_2S_2-Memantine),生成了~(99)Tc~m(V)-Memantine。采用纸层析对此标记物进行质控并检测其体外稳定性。结果显示,湿法的标记率>90%,药盒化标记的标记物经乙酸乙酯萃取纯化后,放化纯度>95%,体外稳定性良好,有望成为一种新的脑功能显像剂。
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| 关 键 词： | 99Tcm标记 美金刚胺 脑受体 显像剂 |
Preliminary Study of 99Tcm-Memantine as an Brain Functional Imaging Agent |
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| ZHANG Jian-kang,ZHOU Xing-qin,YAN Cheng-long,XU Xi-jie,CAO Guo-xian.Preliminary Study of 99Tcm-Memantine as an Brain Functional Imaging Agent[J].Isotopes,2008,21(4). |
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| Authors: | ZHANG Jian-kang ZHOU Xing-qin YAN Cheng-long XU Xi-jie CAO Guo-xian |
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| Affiliation: | ZHANG Jian-kang~1 ZHOU Xing-qin~1 YAN Cheng long~2 XU Xi-jie~1 CAO Guo-xian~1 |
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| Abstract: | N_2S_2-Memantine was labeled with ~(99)Tc~m using stannous fluoride as reducing agent,and the labeling conditions of ~(99)Tc~m-Memantine were optimized,and lyophilized kit of ~(99)Tc~m(V)-Memantine was also developed.The labeling efficiency was more than 90% by TLC and the kit radiochemical purity which was after extraction with ethyl acetate,was more than 95%.The stability was good in room temperature.~(99)Tc~m(V)-Memantine would be a potential brain imaging agent which would need more research work. |
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| Keywords: | ~(99)Tc~m labeling memantine brain receptor imaging agent |
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