Influence of natural polymer coating on novel colon targeting drug delivery system |
| |
Authors: | Valluru Ravi Siddaramaiah T M Pramod Kumar |
| |
Affiliation: | (1) Department of Pharmaceutics, J.S.S College of Pharmacy, S.S Nagar, Mysore, Karnataka, 570015, India;(2) Department of Polymer Science and Technology, S. J. College of Engineering, Mysore, Karnataka, 570006, India |
| |
Abstract: | A novel colon targeted tablet formulation was developed using natural polysaccharides such as chitosan and guar gum as carriers
and diltiazem hydrochloride as model drug. The prepared blend of polymer-drug tablets were coated with two layers, inulin
as an inner coat followed by shellac as outer coat and were evaluated for properties such as average weight, hardness and
coat thickness. In vitro release studies of prepared tablets were carried out for 2 h in pH 1.2 HCl buffer, 3 h in pH 7.4
phosphate buffer and 6 h in simulated colonic fluid (SCF) in order to mimic the conditions from mouth to colon. It was observed
that 4% w/v of rat cecal contents in saline phosphate buffer (SCF) incubated for 24 h provides suitable conditions for in
vitro evaluation of the formulations prepared. The drug release from the coated system was monitored using UV/ Visible spectroscopy.
In vitro studies revealed that the tablets coated with inulin and shellac have controlled the drug release in stomach and
small intestinal environment and released maximum amount of drug in the colonic environment. Among the polymers used, chitosan
was found to be the suitable polymer for colon targeting. The study revealed that polysaccharides as carriers and inulin and
shellac as coating materials can be used effectively for colon targeting of drugs for treating local as well as systemic disorders. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|