| 载不同浓度香丹注射液磷酸钙骨水泥性能研究 |
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| 引用本文： | 李茂红,屈树新,姚宁,郭悦华,张涛,翁杰.载不同浓度香丹注射液磷酸钙骨水泥性能研究[J].无机材料学报,2010,25(5):507-511. |
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| 作者姓名： | 李茂红 屈树新 姚宁 郭悦华 张涛 翁杰 |
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| 作者单位： | 西南交通大学 1. 峨眉校区, 峨眉 614202; 2. 材料科学与工程学院, 材料先进技术教育部重点实验室, 成都 610031; 3. 生命科学与工程学院, 成都 610031 |
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| 基金项目： | 国家自然科学基金(30470484); 教育部新世纪人才基金(NCET-05-0797); 西南交通大学青年教师百人计划 |
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| 摘 要： | 研究载不同浓度香丹注射液(简称香丹)磷酸钙骨水泥(CPC)的理化性能和药物释放,为优化CPC中载入香丹浓度提供理论依据.将香丹与CPC主要原料之一磷酸氢钙混合烘干代替磷酸氢钙制得一系列载不同浓度香丹的CPC,香丹浓度范围在0.05～0.5mL/g.采用Gilmore针、万能材料力学试验机、X射线衍射仪、傅立叶红外光谱仪表征载不同浓度香丹CPC的理化性能,用扫描电镜观察微观形貌,测定载不同浓度香丹CPC的药物释放.结果表明CPC凝结时间随香丹浓度的增加而延长,浓度不高于0.2mL/g的CPC样品凝结时间符合临床要求;抗压强度随香丹含量的增加而增加;香丹加入对CPC转化没有明显影响,但导致水化产物晶体形貌从颗粒状松散搭接转化为片状交织,且浓度越高片状晶体越多.在药物释放的最初4h,载入香丹浓度范围为0.1～0.5mL/g的CPC其释药量符合临床需要.因此,载入香丹浓度范围为0.1～0.2mL/g的CPC凝结时间符合临床要求,比空白CPC具有更高的抗压强度,在初阶段药物释放量符合治疗需求.
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| 关 键 词： | 磷酸钙骨水泥 香丹注射液 性能 浓度 药物释放 |
| 收稿时间： | 2009-08-31 |
| 修稿时间： | 2009-11-23 |
Properties of Calcium Phosphate Cement with various Concentrations of Xiangdan Injection |
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| LI Mao-Hong,QU Shu-Xin,YAO Ning,GUO Yue-Hua,ZHANG Tao,WENG Jie.Properties of Calcium Phosphate Cement with various Concentrations of Xiangdan Injection[J].Journal of Inorganic Materials,2010,25(5):507-511. |
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| Authors: | LI Mao-Hong QU Shu-Xin YAO Ning GUO Yue-Hua ZHANG Tao WENG Jie |
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| Affiliation: | 1. Emei campus, Southwest Jiaotong University, Emei 614202, China; 2. Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China; 3. School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China |
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| Abstract: | Effects of the concentrations of Xiangdan injection on properties of calcium phosphate cement(CPC) and the drug release rate were investigated,which would offer the theory evidence for optimizing the concentration of Xiangdan in CPC.Xiangdan and calcium hydrogen phosphate(DCPD) were mixed and dried to prepare Xiangdan-loaded DCPD which was subsequently used to prepare CPCs containing various concentrations of Xiangdan.The properties of CPCs with various Xiangdan concentrations were characterized by Gilmore ... |
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| Keywords: | calcium phosphate cement xiangdan injection property concentration drug release |
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