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Recapitulating Antioxidant and Antibacterial Compounds into a Package for Tissue Regeneration: Dual Function Materials with Synergistic Effect |
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| Authors: | Minmin Shao Ashkan Bigham Satar Yousefiasl Cynthia K. Y. Yiu Yarabahally R. Girish Matineh Ghomi Esmaeel Sharifi Serap Sezen Ehsan Nazarzadeh Zare Ali Zarrabi Navid Rabiee Ana Cláudia Paiva-Santos Serena Del Turco Baolin Guo Xiangdong Wang Virgilio Mattoli Aimin Wu |
| Affiliation: | 1. Department of Otorhinolaryngology, The Second Affiliated Hospital of Shanghai University, Wenzhou Central Hospital, Wenzhou, 325000 P. R. China;2. Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), 80125 Naples, Italy;3. School of Dentistry, Hamadan University of Medical Sciences, Hamadan, 6517838736 Iran;4. Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, Hong Kong, 999077 P. R. China;5. Centre for Research and Innovations, School of Natural Sciences, BGSIT, Adichunchanagiri University, B.G. Nagara, Mandya District, Mandya, Karnataka, 571448 India;6. School of Chemistry, Damghan University, Damghan, 36716-45667 Iran;7. Department of Tissue Engineering and Biomaterials, School of Advanced Medical Sciences and Technologies, Hamadan University of Medical Sciences, Hamadan, 6517838736 Iran;8. Faculty of Engineering and Natural Sciences, Sabanci University, Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı, Tuzla, Istanbul, 34956 Turkey;9. Department of Biomedical Engineering, Faculty of Engineering and Natural Sciences, Istinye University, Sariyer, Istanbul, 34396 Turkey;10. Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, Western Australia, 6150 Australia School of Engineering, Macquarie University, Sydney, New South Wales, 2109 Australia;11. Department of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, 3000-548 Coimbra, Portugal;12. National Research Council, Institute of Clinical Physiology, 56124 Pisa, Italy Istituto Italiano di Tecnologia, Centre for Materials Interfaces, 56025 Pontedera, Pisa, Italy;13. State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049 P. R. China;14. Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Fudan University Shanghai Medical College, Shanghai, 200032 P. R. China;15. Istituto Italiano di Tecnologia, Centre for Materials Interfaces, 56025 Pontedera, Pisa, Italy;16. Department of Orthopaedics, Key Laboratory of Structural Malformations in Children of Zhejiang Province, Key Laboratory of Orthopaedics of Zhejiang Province, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000 P. R. China |
| Abstract: | Oxidative damage and infection can prevent or delay tissue repair. Moreover, infection reinforces reactive oxygen species (ROS) formation, which makes the wound's condition even worse. Therefore, the need for antioxidant and antibacterial agents is felt for tissue regeneration. There are emerging up-and-coming biomaterials that recapitulate both properties into a package, offering an effective solution to turn the wound back into a healing state. In this article, the principles of antioxidant and antibacterial activity are summarized. The review starts with biological aspects, getting the readers to familiarize themselves with tissue barriers against infection. This is followed by the chemistry and mechanism of action of antioxidant and antibacterial materials (dual function). Eventually, the outlook and challenges are underlined to provide where the dual-function biomaterials are and where they are going in the future. It is expected that the present article inspires the designing of dual-function biomaterials to more advanced levels by providing the fundamentals and comparative points of view and paving the clinical way for these materials. |
| Keywords: | antimicrobial antioxidant nano-architectures nanoparticles tissue engineering |