| 阿达帕林的精制工艺研究 |
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| 引用本文： | 杨昌云,赵从东. 阿达帕林的精制工艺研究[J]. 广州化工, 2010, 38(8): 162-163 |
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| 作者姓名： | 杨昌云 赵从东 |
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| 作者单位： | 1. 解放军180医院药剂科,福建,泉州,362000
2. 海南职业技术学院生物工程学院,海南,海口,570216 |
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| 摘 要： | 在negishi偶联后处理步骤中采用EDTA-2Na水溶液洗涤以除去无机盐。以四氢呋喃-甲苯重结晶,采用保温析晶,干燥后于甲醇和去离子水中回流搅拌,前后两次80℃真空干燥。结果单一杂质:0.06%、总杂质:0.17%;重金属、炽灼残渣和溶剂残留均能符合规定。
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| 关 键 词： | 阿达帕林 精制工艺 溶剂残留 |
Study on Purification Process of Adapalene |
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| YANG Chang-yun,ZHAO Cong-dong. Study on Purification Process of Adapalene[J]. GuangZhou Chemical Industry and Technology, 2010, 38(8): 162-163 |
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| Authors: | YANG Chang-yun ZHAO Cong-dong |
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| Affiliation: | 1 Pharmaceutical Department,the PLA 180 Hospital,Fujian Quanzhou 36200;2 Bioengineer-ing Institute,Hainan College of Vocation and Technique,Hainan Haikou 570216,China) |
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| Abstract: | Aqueous solution of EDTA-2Na was introduced in the work-up procedures of negishi coupling.With controlling crystallization temperature,the crude product was recrystallized by tetrahydrofuran-toluene and stirred at refluxing temperature in methanol and deionized water solution,with both before and after vacuum drying in 80℃ and crystallization,respectively.The results showed that the largest impurity result was 0.06% ,the total impurities result was 0.17% ,and none of heavy metal,ignition residue and residual solvent was found to exceed quality limit. |
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| Keywords: | adapalene purification process residual solvent |
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