| KO~tBu促进的有机叠氮和末端炔烃的环加成反应改进研究 |
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| 引用本文： | 吴禄勇,陈昱学,宋鑫明,阮超飞,陈光英,宋小平. KO~tBu促进的有机叠氮和末端炔烃的环加成反应改进研究[J]. 广东化工, 2012, 39(5): 7-8 |
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| 作者姓名： | 吴禄勇 陈昱学 宋鑫明 阮超飞 陈光英 宋小平 |
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| 作者单位： | 海南师范大学化学化工学院海南省热带药用植物化学省部共建教育部重点实验室,海南海口,571158 |
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| 基金项目： | 海南省高等学校科学研究项目，海南省热带药用植物化学省部共建教育部重点实验室开放基金项目 |
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| 摘 要： | 文章系统研究了叔丁醇钾促进下芳基叠氮和取代苯乙炔的环加成反应。在等摩尔数的叔丁醇钾作用下,当溶剂为DMF时,反应效果最佳,产率高达92%。其他的芳基叠氮和苯乙炔的反应研究结果表明,芳基叠氮和苯乙炔在此环加成反应中具有良好的反应适应性。
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| 关 键 词： | 1,2,3-三唑 叠氮 苯乙炔 环加成反应 叔丁醇钾 |
KOtBu-promoted Cycloaddition Reaction from Azides and Terminal Alkynes for Synthesis of 1,5-diaryl 1,2,3-triazoles |
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| Wu Luyong,Chen Yuxue,Song Xinming,Ruan Chaofei,Chen Guangying,Song Xiaoping. KOtBu-promoted Cycloaddition Reaction from Azides and Terminal Alkynes for Synthesis of 1,5-diaryl 1,2,3-triazoles[J]. Guangdong Chemical Industry, 2012, 39(5): 7-8 |
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| Authors: | Wu Luyong Chen Yuxue Song Xinming Ruan Chaofei Chen Guangying Song Xiaoping |
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| Affiliation: | (Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Educatio,College of Chemistry and Chemical Engineeingr,Hainnan Normal University,Haikou 571158,China) |
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| Abstract: | The reaction of phenyl azide and phenylacetylene was investigated promoted by KOtBu in DMF.Under 1.0 equiv.of KOtBu,the best result was given,and corresponding 1,5-diaryl-1,2,3-triazoles was generated.Others aromatic azides and aromatic acetylenes were suitable in the cycloaddition to construct 1,5-diaromatic 1,2,3-triazoles in good to excellent yields. |
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| Keywords: | alkynes azides cycloaddition 1 2 3-triazoles KOtBu |
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