| 萘普生分子印迹拆分过程热力学研究 |
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| 引用本文： | 焦飞鹏,黄可龙,于金刚,彭霞辉,赵学辉,宁凤容. 萘普生分子印迹拆分过程热力学研究[J]. 材料导报, 2005, 19(8): 114-116 |
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| 作者姓名： | 焦飞鹏 黄可龙 于金刚 彭霞辉 赵学辉 宁凤容 |
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| 作者单位： | 中南大学化学化工学院,长沙,410083 |
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| 基金项目： | 国家自然科学基金，湖南省自然科学基金 |
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| 摘 要： | 采用4-乙烯基吡啶为功能单体,三甲氧基丙烷三甲基丙烯酸酯为交联剂,制备出(S)-萘普生的分子印迹聚合物,并将其用作高效液相色谱固定相,对其进行了评价.研究了流动相流速、不同功能单体和柱温对拆分效果的影响,测定出分离过程的热力学参数,证明萘普生分子印迹拆分过程是焓控过程.
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| 关 键 词： | 分子印迹 拆分 萘普生 热力学 |
Study on Process of Thermodynamics for Chiral Separation of Naproxen in Molecular Imprinting |
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| JIAO Feipeng,Huang Kelong,YU Jingang,PENG Xiahui,Zhao Xuehui,NING Fengrong. Study on Process of Thermodynamics for Chiral Separation of Naproxen in Molecular Imprinting[J]. Materials Review, 2005, 19(8): 114-116 |
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| Authors: | JIAO Feipeng Huang Kelong YU Jingang PENG Xiahui Zhao Xuehui NING Fengrong |
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| Abstract: | A chiral stationary phase for the enantioselective separation of naproxen can be prepared by molecu- lar imprinting,in which 4-vinylpyridine(functional monomer)and trimethylol propane trimethacrylate are copolymer- ized in the presence of S-naproxen.Racemic naproxen is efficiently resolved on the molecular imprinting polymer.Fur- thermore,different functional monomers,flow rate in the mobile phase,temperature of column are investigated.The thermodynamic parameters are estimated,it is found that enantioselective separation is enthalpy controlled. |
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| Keywords: | molecular imprinting resolution naproxen thermodynamics |
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