电纺直写制备聚己内酯支架形貌及精度

作为一种新型的微纳制造技术,熔体直写电纺被广泛用于组织工程支架的可控制备,有序的纤维沉积是该领域应用的前提条件。对于支架成型精度的探究,本文使用生物可降解材料聚己内酯（PCL）,采用自行设计的熔体电纺三维可控成型设备进行实验,考察了纤维间距对二维并行纤维沉积形貌及成型精度的影响,以及纺丝电压和网格大小对三维网格结构形貌及精度影响。结果表明,随着并行纤维设定距离的增大,纤维的沉积误差减小,并最终趋于平稳。对于三维网格结构,随电压的增加,最大沉积层数量先增大后减小,当纺丝电压为6kV时达到最大沉积层数15层。成型精度误差先减小后增大,当纺丝电压为7kV时,精度最高误差小于5%。随设定网格边长的增大,沉积层数不断增大。成型精度逐渐提高,当网格边长大于等于1.5mm时,沉积误差趋于稳定,并维持在5%左右。

Morphology and accuracy of polycaprolactone (PCL) scaffolds prepared by electrospinning direct writing

As a new micro-nano manufacturing technology, melt direct-write electrospinning is widely used for the controllable preparation of tissue engineering scaffolds, and ordered fiber deposition is a prerequisite for application in this field. For the exploration of stent forming precision, the biodegradable material polycaprolactone (PCL) was used, and the self-designed melt electrospinning three-dimensional controllable molding equipment was applied for the experiment. The effects of fiber spacing on the morphology and molding accuracy of two-dimensional parallel fiber deposition, as well as the influence of spinning voltage and mesh size on the shape and precision of three-dimensional grid structure were investigated. The results showed that with the increase of setting distance of parallel fibers, the deposition error of fibers decreased and eventually stabilized. For the three-dimensional grid structure, as the voltage increases, the maximum number of deposited layers first increased and then decreased. When the spinning voltage was 6 kV, the maximum number of deposited layers was 15. The molding accuracy error first reduced and then increased. When the spinning voltage was 7 kV, the highest precision error was less than 5%. As the length of the grid increased, the number of layers continuously increased and the molding accuracy was gradually improved. When the side length of the mesh was greater than or equal to 1.5 mm, the deposition error tended to be stable and was maintained at about 5%.