Assessing methods for blood cell cytotoxic responses to inorganic nanoparticles and nanoparticle aggregates |
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Authors: | Díaz Belén Sánchez-Espinel Christian Arruebo Manuel Faro José de Miguel Encarnación Magadán Susana Yagüe Clara Fernández-Pacheco Rodrigo Ibarra M Ricardo Santamaría Jesús González-Fernández Africa |
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Affiliation: | Faculty of Biology, University of Vigo, Vigo, Pontevedra, Spain. |
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Abstract: | Inorganic nanoparticles (NPs) show great potential for medicinal therapy. However, biocompatibility studies are essential to determine if they are safe. Here, five different NPs are compared for their cytotoxicity, internalization, aggregation in medium, and reactive oxygen species (ROS) production, using tumoral and normal human blood cells. Differences depending on the cell type are analyzed, and no direct correlation between ROS production and cell toxicity is found. Results are discussed with the aim of standardizing the procedures for the evaluation of the toxicity. |
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Keywords: | cytotoxicity magnetic nanoparticles reactive oxygen species silica |
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